About the radical binding effect of Flavin7
The research of antioxidants of natural vegetable and fruit origin, as well as the production of such products is going through a renaissance these days. A large group of antioxidant compounds of natural origin is constituted by flavonoids. These produce their antioxidant effect through several mechanisms, of which their radical binding effect is the most important. The connection between lipid peroxidisation and oxidative stress causing pathologic changes has been proven beyond doubt. Lipid peroxidisation plays a central role in the emergence of cardio-vascular diseases.
Keeping radicals with reactive oxygen contents at a level in the system has a basic significance from the aspect of vital processes. The oxidative damage to DNA is in connection with the mutatogene and calciogene processes. Flavin 7 contains a large number of flavonoid components. There are no certified and public data at disposal about the antioxidant radical-binding effect of other diet-supplement products of flavonoid contents, with medical effect, on the market at present. Now in the case of Flavin 7, our company is able to publish data to professionals and those interested that undoubtedly prove the radical binding effect of the product.
We have proven the radical binding effect as well as the change of the effect in time with several kinds of stable free radicals. At the same time we have compared the product with the effect of other known, antioxidant products or products with flavonoid contents on the market. The results are announced in the form of papers and published in professional journals.
Mechanisms of flavonoids for the maintenance of redox balance. (PMCID: PMC7402123)
It has long been known that oxidatives stress caused by free radicals has an important role in the induction of several diseases, in the field of cardiovascular, tumor, nervous system or musculoskeletal illnesses among others. Due to environmental harms, negative nutritional habits and addictions, oxidative strain is greatly present in our lives. Therefore an important role is to be given to the consumption of antioxidants, among which, polyphenols and flavonoids are efficient free radical neutralizers.
It has been revealed in several studies that various antineoplastic therapies and tumor progression can increase the formation of reactive types of oxygen (ROS), that is oxydative stress whose enhanced risk may provoke the impairment of renal proximal tubules. According to statistics, kidney failure occurs more frequently in tumor diseases, however it has also been proved that the consumption of antioxidants may moderate renal toxicity caused by chemotherapy agents. This involves that antioxidant therapies can be beneficial to patients with tumor diseases. Plyphenols an flavonoids derived from plants have strong antioxidant features and they have proved to be efficient against oxidative stress in several studies.
Flavin7 (F7) of natural vegetal origin and with significant polyphenol complex content was examined in this study. Great concentration of F7 contains natural polyphenols which have a potential antioxidant activity. The aim of this study was to determine whether F7 shows antioxidant features in the proximal tubular cells of mice kidneys. In order to achieve this, oxidative stress was induced in a renal cell culture for 24 hours, using hydrogen-peroxide, which can cause significant damages. Formation of reactive types of oxygen (ROS) were determined following this. Then, it was analysed how ROS production was changing during the pre-treatment with F7.
These results show that ROS production induced with hydrogen-peroxide was deteriorated by F7 application, moreover in the group pre-treated with F7 it blocked ROS production at all. It can be stated obviously that Flavin7 with significant polyphenol content can inhibit the cytotoxicitiy induced by hydrogen-peroxide and the apoptosis as a consequence of the former one. This study proves that the application of Flavin7 in the therapy of tumor diseases improves the survival chances of patients.
